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MAN UTD XI (4-2-3-1): David de Gea; Aaron Wan-Bissaka, Victor Lindelof, Harry Maguire (c), Luke Shaw; Paul Pogba, Nemanja Matic; Mason Greenwood, Bruno Fernandes, Marcus Rashford; Anthony Martial.
BRIGHTON XI (3-4-2-1): Mat Ryan; Ben White, Lewis Dunk (c), Adam Webster; Tariq Lamptey, Adam Lallana, Steven Alzate, Solly March; Leandro Trossard, Neal Maupay; Aaron Connolly.
Manchester United show three changes from their opening game defeat against Crystal Palace.
Wan-Bissaka is in for Fosu-Mensah at right-back, while Matic is preferred to McTominay alongside Pogba in the engine room, meaning only a place on the bench for Van de Beek.
The other alteration comes in attack as Greenwood replaces Daniel James, who is not in the squad today.